Neuronal inclusions of Parkinson's disease
Identifieur interne : 006142 ( Main/Exploration ); précédent : 006141; suivant : 006143Neuronal inclusions of Parkinson's disease
Auteurs : Gibb [Royaume-Uni] ; T. Scott [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1991.
English descriptors
- KwdEn :
- Antibodies, Monoclonal (diagnostic use), Autonomic Nervous System (pathology), Brain (pathology), Cerebral Cortex (pathology), Filament, Ganglia, Sympathetic (pathology), Humans, Immunoenzyme Techniques, Inclusion Bodies (ultrastructure), Intermediate Filament Proteins (analysis), Lewy body, Limbic System (pathology), Locus Coeruleus (pathology), Locus ceruleus, Microscopy, Electron, Nerve Degeneration (physiology), Neurofilament Proteins, Neurons (ultrastructure), Pale body, Parkinson's disease, Substantia nigra, Vagus Nerve (pathology).
- MESH :
- chemical , analysis : Intermediate Filament Proteins.
- chemical , diagnostic use : Antibodies, Monoclonal.
- pathology : Autonomic Nervous System, Brain, Cerebral Cortex, Ganglia, Sympathetic, Limbic System, Locus Coeruleus, Vagus Nerve.
- physiology : Nerve Degeneration.
- ultrastructure : Inclusion Bodies, Neurons.
- Humans, Immunoenzyme Techniques, Microscopy, Electron, Neurofilament Proteins.
Abstract
Two distinct neuronal inclusions occur in Parkinson's disease. The Lewy body is the diagnostic hallmark and is recognized by its eosinophilic body and unstained halo. It can be found in specific regions of the nervous system, where its frequency, size, shape, and structure differ. Large neurons of the dorsal vagal nucleus and sympathetic ganglia often contain particularly large quantities of Lewy‐body‐like matter. It consists of filament in the outer part and electron dense material in the core, the outer part staining with silver and with antibodies to neurofilament and tubulin. The pale body is restricted to the substantia nigra and locus ceruleus. It does not react with conventional stains, silver, or neurofilament antibodies, and has a homogeneous structure with a granular and vesicular surface texture. It contains sparse granular matter, vacuoles, and filaments, surrounded by melanin. The Lewy body and pale body may be juxtaposed or contiguous in some cells, but their distinct appearances and structures indicate that they are separate inclusions.
Url:
DOI: 10.1002/mds.870060103
Affiliations:
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J." last="Lees">Andrew Lees (neurologue)</name><affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0311CF9F2E109F816F59E5090FC9DC53EFBE8260</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1002/mds.870060103</idno><idno type="url">https://api.istex.fr/document/0311CF9F2E109F816F59E5090FC9DC53EFBE8260/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000C17</idno><idno type="wicri:Area/Istex/Curation">000C17</idno><idno type="wicri:Area/Istex/Checkpoint">004285</idno><idno type="wicri:doubleKey">0885-3185:1991:Gibb:neuronal:inclusions:of</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:1848677</idno><idno type="wicri:Area/PubMed/Corpus">004E28</idno><idno type="wicri:Area/PubMed/Curation">004E28</idno><idno type="wicri:Area/PubMed/Checkpoint">004E08</idno><idno type="wicri:Area/Ncbi/Merge">002140</idno><idno type="wicri:Area/Ncbi/Curation">002140</idno><idno type="wicri:Area/Ncbi/Checkpoint">002140</idno><idno type="wicri:doubleKey">0885-3185:1991:Gibb W:neuronal:inclusions:of</idno><idno type="wicri:Area/Main/Merge">009446</idno><idno type="wicri:Area/Main/Curation">006142</idno><idno type="wicri:Area/Main/Exploration">006142</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Neuronal inclusions of Parkinson's disease</title><author><name sortKey="Gibb" sort="Gibb" uniqKey="Gibb" last="Gibb">Gibb</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>University Department of Neurology, King's College School of Medicine and Dentistry, Queen Square</wicri:orgArea></affiliation></author><author><name sortKey="Scott, T" sort="Scott, T" uniqKey="Scott T" first="T." last="Scott">T. Scott</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>Neuropathology Department, National Hospitals for Nervous Diseases, Maida Vale, Queen Square</wicri:orgArea></affiliation></author><author><name sortKey="Lees, A J" sort="Lees, A J" uniqKey="Lees A" first="A. J." last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>National Hospital for Nervous Diseases, Queen Square</wicri:orgArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1991">1991</date><biblScope unit="vol">6</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="2">2</biblScope><biblScope unit="page" to="11">11</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">0311CF9F2E109F816F59E5090FC9DC53EFBE8260</idno><idno type="DOI">10.1002/mds.870060103</idno><idno type="ArticleID">MDS870060103</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal (diagnostic use)</term><term>Autonomic Nervous System (pathology)</term><term>Brain (pathology)</term><term>Cerebral Cortex (pathology)</term><term>Filament</term><term>Ganglia, Sympathetic (pathology)</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Inclusion Bodies (ultrastructure)</term><term>Intermediate Filament Proteins (analysis)</term><term>Lewy body</term><term>Limbic System (pathology)</term><term>Locus Coeruleus (pathology)</term><term>Locus ceruleus</term><term>Microscopy, Electron</term><term>Nerve Degeneration (physiology)</term><term>Neurofilament Proteins</term><term>Neurons (ultrastructure)</term><term>Pale body</term><term>Parkinson's disease</term><term>Substantia nigra</term><term>Vagus Nerve (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Intermediate Filament Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Autonomic Nervous System</term><term>Brain</term><term>Cerebral Cortex</term><term>Ganglia, Sympathetic</term><term>Limbic System</term><term>Locus Coeruleus</term><term>Vagus Nerve</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Nerve Degeneration</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Inclusion Bodies</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Immunoenzyme Techniques</term><term>Microscopy, Electron</term><term>Neurofilament Proteins</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Two distinct neuronal inclusions occur in Parkinson's disease. The Lewy body is the diagnostic hallmark and is recognized by its eosinophilic body and unstained halo. It can be found in specific regions of the nervous system, where its frequency, size, shape, and structure differ. Large neurons of the dorsal vagal nucleus and sympathetic ganglia often contain particularly large quantities of Lewy‐body‐like matter. It consists of filament in the outer part and electron dense material in the core, the outer part staining with silver and with antibodies to neurofilament and tubulin. The pale body is restricted to the substantia nigra and locus ceruleus. It does not react with conventional stains, silver, or neurofilament antibodies, and has a homogeneous structure with a granular and vesicular surface texture. It contains sparse granular matter, vacuoles, and filaments, surrounded by melanin. The Lewy body and pale body may be juxtaposed or contiguous in some cells, but their distinct appearances and structures indicate that they are separate inclusions.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gibb" sort="Gibb" uniqKey="Gibb" last="Gibb">Gibb</name></region><name sortKey="Lees, A J" sort="Lees, A J" uniqKey="Lees A" first="A. J." last="Lees">Andrew Lees (neurologue)</name><name sortKey="Scott, T" sort="Scott, T" uniqKey="Scott T" first="T." last="Scott">T. Scott</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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